The magnitude and frequency of disease outbreaks and health emergencies in Africa, coupled with the expansion of diseases such as cholera, Ebola Virus Disease, and Lassa fever, underscore the urgent need for robust preparedness and capacity building among WHO AFRO Member States. Furthermore, persistent outbreaks of vaccine-preventable diseases like measles, meningitis, and yellow fever, along with zoonotic diseases such as Rift Valley fever and anthrax, highlight the importance of maintaining operational readiness.